RESUMO
Eccrine poroma frequently occurs as a solitary tumour, and only a few reports have described the occurrence of multiple lesions. Multiple eccrine poromas, or eccrine poromatosis, may occur in patients who have undergone radiotherapy and/or polychemotherapy. We report here four cases of multiple eccrine poromas in patients who were either undergoing, or had undergone, intensive chemotherapy (from 6 months to 16 years prior to onset). Three patients had non-Hodgkin's lymphoma and one had malignant fibrous histiocytosis. The number of lesions varied from 3 to > 20 in each patient, and all the lesions occurred on non-irradiated skin. The histopathological features were consistent with those of eccrine poroma, Pinkus type. In addition to radiation therapy, intensive chemotherapy may play a role in the pathogenesis of multiple eccrine poromas even many years after treatment.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Histiocitoma Fibroso Maligno/tratamento farmacológico , Linfoma não Hodgkin/tratamento farmacológico , Poroma/induzido quimicamente , Neoplasias das Glândulas Sudoríparas/induzido quimicamente , Idoso , Idoso de 80 Anos ou mais , Biópsia , Dermoscopia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Poroma/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Fatores de TempoRESUMO
Eccrine squamous syringometaplasia is a histopathologic pattern that has mainly been described in patients receiving chemotherapy. Its association to nonchemotherapeutic agents is rare, with very few cases reported in the literature. We present the case of a 55-year-old patient with schizophrenia, who developed a skin eruption 5 weeks after initiating treatment with olanzapine. The histopathologic study revealed squamous syringometaplasia of the dermal eccrine ducts.
Assuntos
Antipsicóticos/efeitos adversos , Benzodiazepinas/efeitos adversos , Glândulas Écrinas/efeitos dos fármacos , Esquizofrenia/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/induzido quimicamente , Biópsia , Fármacos Dermatológicos/uso terapêutico , Substituição de Medicamentos , Glândulas Écrinas/patologia , Humanos , Masculino , Metaplasia , Pessoa de Meia-Idade , Olanzapina , Risperidona/uso terapêutico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/patologia , Resultado do TratamentoRESUMO
Eccrine squamous syringometaplasia is a histologic finding associated with chemotherapy administration and other cutaneous diseases. Concentration of the chemotherapeutic agents is believed to effect toxic changes in these epithelial structures. We report the first case of vincristine-induced eccrine squamous syringometaplasia in a 12-year-old patient undergoing treatment for rhabdomyosarcoma.
